N. M. Nizardo, D. Schanzenbach, E. Schönemann, A. Laschewsky
Exploring Poly(ethylene glycol)-Polyzwitterion Diblock Copolymers as Biocompatible Smart Macrosurfactants Featuring UCST-Phase Behavior in Normal Saline Solution.
Polymers 2018, 10, 325
DOI: 10.3390/polym10030325
Thermo-responsive polymeric surfactants in form of nonionic-zwitterionic diblock copolymers were made from biocompatible blocks via ATRP using a PEG macroinitiator and a set of sulfobetaine and sulfabetaine monomers. The polymers were designed to show upper critical solution temperature (UCST) behavior under physiologically relevant conditions, i.e., between 30 and 50°C in physiological saline solution. The possibility for UCST-transition triggered encapsulation and release of solvatochromic fluorescent dyes as model \"cargos\" was explored.
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