H. R. Arias, D. Feuerbach, B. Schmidt, M. Heydenreich, C. Paz, M. O. Ortells
Drimane Sesquiterpenoids Noncompetitively Inhibit Human α4β2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human α3β4 and α7 Subtypes
J. Nat. Prod. 2018, 81, 811-817
DOI: 10.1021/acs.jnatprod.7b00893
Drimane sesquiterpenoids were isolated from the Canelo tree (Drimys winteri), which is native in Southern Chile and considered as a sacred plant by the local people, because of its medicinal properties. This paper describes the joint efforts of scientists from five institutions, including our institute, in five countries toward the isolation, structure elucidation and pharmacological evalutation of secondary metabolites with sesquiterpenoid structure from this plant. Some of the compounds display inhibitory activity towards human nicotinic acetylcholine receptors (AChRs) on a low micromolar level.
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