C. Schultze, B. Schmidt
Prenylcoumarins in One or Two Steps by a Microwave-Promoted Tandem Claisen Rearrangement/Wittig Olefination/Cyclization Sequence
J. Org. Chem. 2018, 83, 5210-5224
DOI: 10.1021/acs.joc.8b00667
Naturally occurring 8-prenyl coumarins are ubiquitious secondary metabolites. This paper describes a short and high-yielding route to their synthesis, based on a tandem Claisen-rearrangement/Wittig-olefination sequence and a highly selective cross metathesis.
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