M. Czarnecki, P. Wessig
Scaling Up UV-Mediated Intramolecular Photodehydro-Diels Alder Reactions Using a Homemade High-Performance Annular Continuous-Flow Reactor
Org. Process Res. Dev. 2018, 22, 1823-1827
DOI: 10.1021/acs.oprd.8b00353
Here we present a self-made annular continuous-flow reactor that can be used in the UV/vis range in an internal numbering-up manner. As a model reaction, we chose a powerful batch-scale-limited benzoannelation method, namely, an intramolecular photodehydro-Diels-Alder (IMPDDA) reaction. The scale-up potential of this particular photochemical benchmark reaction toward the preparation of macrocylic (1,7)naphthalenophanes by variation of selected flow parameters is presented.
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