A. R. Sardarian, I. Dindarloo Inaloo, A. R. Modarresi-Alam, E. Kleinpeter, U. Schilde
Metal-Free Regioselective Monocyanation of Hydroxy-, Alkoxy- and Benzyloxyarenes by Potassium Thiocyanate and Silica Sulfuric Acid as a Cyanating Agent
J. Org. Chem. 2019, 84, 1748-1756
DOI: 10.1021/acs.joc.8b02191
A novel and efficient metal- and solvent-free regioselective para-C-H cyanation of hydroxy-, alkoxy-, and benzyloxyarene derivs. has been introduced, using nontoxic potassium thiocyanate as a cyanating reagent in the presence of silica sulfuric acid (SSA). The desired products are obtained in good to high yields without any toxic byproducts
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