Publikation

E. Schönemann, .A. Laschewsky, E. Wischerhoff, J. Koc, A. Rosenhahn
Surface Modification by Polyzwitterions of the Sulfabetaine-Type, and Their Resistance to Biofouling
Polymers 2019, 11, 1014
DOI: 10.3390/polym11061014
We synthesize a series of new zwitterionic polymers that combine ammonium and sulfate groups in their betaine moieties. The chemical structure of these so-called poly(sulfabetaine)s is varied systematically for monomers carrying methacrylate, methacrylamide, or styrene moieties as polymerizable groups. Free radical polymerization yields high molar mass homopolymers. Solubilities in most solvents are low, but brine and lower fluorinated alcohols were effective solvents in most cases. A set of sulfabetaine copolymers containing ~1 mol % (based on the repeat units) of reactive benzophenone methacrylate is prepared, spin-coated onto solid substrates, and photo-cured. The resistance of these films against the nonspecific adsorption of model proteins BSA and fibrinogen is explored. The various polyzwitterions reduce protein adsorption strongly compared to films of poly(n butyl methacrylate) that are used as negative control. The poly(sulfabetaine)s show mostly slightly higher anti-fouling activity than their poly(sulfobetaine) analogues, though detailed efficacies depend on the individual polymer–protein pairs. Best samples approach the excellent performance of a poly(oligo(ethylene oxide) methacrylate) reference.
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