G. Kwesiga, A. Kelling, S. Kersting, E. Sperlich, M. von Nickisch-Rosenegk, B. Schmidt
Total Syntheses of Prenylated Isoflavones from Erythrina sacleuxii and Their Antibacterial Activity: 5-Deoxy-3´-prenylbiochanin A and Erysubin F
J. Nat. Prod. 2020, 83, 3445-3453. 2020, 83, 3445-3453
DOI: 10.1021/acs.jnatprod.0c00932
The synthesis of prenylated isoflavones that were previously isolated from the East-African Medicinal plant Erythrina sacleuxii is described via a flavanone-isoflavone oxidative rearrangement mediated by hypervalent iodine compounds. In contrast to previous reports, synthetic erysubin F showed antibiotic activity against methicillin-resistant Staphylococcus aureus at micromolar concentrations.
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