Krause, A.; Sperlich, E.; Schmidt, B.
Matsuda–Heck arylation of itaconates: a versatile approach to heterocycles from a renewable resource.
Org. Biomol. Chem. 2021, 19, 4292-4302
DOI: 10.1039/D1OB00392E
Itaconic acid is a basic chemical from a renewable resource that has mainly found applications for polymers but has hardly been used for fine chemicals production. We report applications of itaconic acid derivatives in Pd-catalyzed arylation reactions with arene diazonium salts, the so-called Matsuda-Heck reaction, and the conversion of the coupling products to previously difficult to access benzazepinones.
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