Publikation

B. Schmidt, N. Elizarov, U. Schilde, A. Kelling
Dual Role of Acetanilides: Traceless Removal of a Directing Group through Deacetylation/Diazotation and Palladium-Catalyzed C–C-Coupling Reactions
J. Org. Chem. 2015, 80, 4223-4234
DOI: 10.1021/acs.joc.5b00272
Palladium(II) acetate is the precatalyst for Pd2+-catalyzed oxidative C–H-activation reactions and for Pd0-catalyzed coupling and cross-coupling reactions. Both types of transformations can be used for regioselective arene functionalization, with the acetamide group playing a dual role, first as a catalyst directing group and then as a leaving group precursor.
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