D. Kedracki, S. K. Filippov, N. Gour, H. Schlaad, C. Nardin
Formation of DNA-Copolymer Fibrils Through an Amyloid-Like Nucleation Polymerization Mechanism
Macromolecular Rapid Communications 2015, 36, 768
DOI: 10.1002/marc.201400728
Conjugation of a hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer, which organizes in fibrils upon direct dissolution in water. Supported by circular dichroism, atomic force microscopy, transmission electron microscopy, and scattering data, fibrils are formed through inter- and intramolecular hydrogen bonding between hydrogen accepting amide groups along the polymer backbone and hydrogen donating nucleic acid grafts leading to the formation of hollow tubes.
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