A. Prestel, H. M. Möller
Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides
Chem. Commun. 2016, 52, 701-704
DOI: 10.1039/C5CC06848G
The selective uptake of compounds into specific cells of interest is a major objective in cell biology and drug delivery. By incorporation of a novel, thermostable azobenzene moiety we generated peptides that can be switched optically between an inactive state and an active, cell-penetrating state with excellent spatio-temporal control.
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