N. Vishnevetskaya, V. Hildebrand, B.-J. Niebuur, I. Grillo, S. Filippov, A. Laschewsky, P. Müller-Buschbaum, C. M. Papadakis
Aggregation behavior of doubly thermo-responsive polysulfobetaine-b-poly(N-isopropylacrylamide) diblock copolymers
Macromolecules 2016, 49, 6655
DOI: 10.1021/acs.macromol.6b01186
A twofold thermo-responsive diblock copolymer containing a zwitterionic polysulfobetaine block (P-SPP) and a non-ionic block of poly(N-isopropylacrylamide) (P-NiPAm) was synthesized. While both homopolymers P-SPP and P-NIPAM are thermoresponsive in aqueous solution, exhibiting upper and lower critical solution temperatures (UCST and LCST), respectively, the diblock copolymer undergoes "schizophrenic" temperature-induced aggregation. This is investigated in detail by turbidimetry and small-angle neutron scattering (SANS), revealing marked differences of the polymer micelles formed below the UCST-type and above the LCST-type transitions.
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