Publikation

Marin, V.; Iturra, A.; Opazo, A.; Schmidt, B.; Heydenreich, M.; Ortiz, L.; Jiménez, V. A.; Paz, C.
Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against Candida Yeast by Inhibition of Lanosterol 14-Alpha Demethylase
Biomolecules 2020, 10, 1101
DOI: 10.3390/biom10081101
Isodrimeninol is a natural product isolated from the bark of the tree Drimys winteri. It was used for the synthesis of four other sesquiterpenoids through oxidation with PCC. The products were tested for their antifungal activity against various Candida species that cause Candidiasis, an opportunistic yeast infection responsible for more than 50000 deaths per year worldwide. Isodrimeninol and one of its oxidation products bind to the catalytic site of lanosterol-14-alpha-demethylase as shown by in-silico analysis, which provides the mechanistic rationale for the observed antifungal activity.
 
The paper results from a collaborative project of Prof. Cristian Paz from the Universidad de la Frontera in Temuco, Chile, with Dr. Matthias Heydenreich and Prof. Bernd Schmidt.
 
Prof. Paz is a regular visiting scientist at our department.
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